Zerumbone is a natural product found in the gingers Zingiber aromaticum and Zingiber zerumbet. Cancer. Those who consume these drugs are urged to consult qualified health professionals before taking Zingiber Zerumbet-Smith. In the DOV 13 cell line, apoptosis was seen only with 4-hydroxyperoxycyclophosphamide. Medicinal Properties of Zerumbone: suppresses free radical generation; anti-inflammatory; This problem was overcome by employing an improved H2-producing cathode composed of a Co-P alloy. Following 4 weeks of the treatment with 10 ml/kg of the aqueous CS extract and 2ml/kg of zerumbone, histopathological changes of joints articular cartilages decreased and the immunoreactivity in the synovial membranes improved. pyrimidin-5-yl] methanol (PM), benzotriazole and piperazine derivatives were synthesized by N-alkylation, acylation and click More evidence is needed to rate the effectiveness of tribulus for these uses. ZER induced nuclear localization of the transcription factor Nrf2 that binds to antioxidant response element (ARE) of the phase II enzyme genes, suggesting that ZER is a potential activator of the Nrf2/ARE-dependent detoxification pathway. Nadzri et al., prepared Zerumbone inclusion complex with HP-β-CD and characterized the complexes. for isobutanol and 3-methyl-1-butanol production [37], was fed with H2 and O2. Evaluation of OA changes following 4 weeks of treatment was done through macroscopic and microscopic examinations supported with radiography to the knee joints. The 'Awapuhi is said to be one of the Kinolau, multiple forms, of the Hawaii deity Kane. About 40–70% of drug molecules in the clinical development pipeline suffer from one of either low aqueous solubility, poor absorption, or extremely low bioavailability. Using the automated oxygen radical absorbance capacity (ORAC) assay developed in our laboratory, we determined the antioxidant capacity of 14 anthocyanins including the aglycons delphinidin, cyanindin, pelargonidin, malvidin, peonidin, and their derivatives with different sugar linkages. The initially used MES by Torella et al. The anticancer effect of sesquiterpene lactones and their molecular mechanism are reviewed by Zhang et al. cancer cell lines including HepG-2, LU-1, RD and FL. This new anticancer bioactive compound from Z. zerumbet was investigated for its activity and mechanism in human liver cancer cell lines. Zingiber blancoi Hassk. Compounds 1-6 were evaluated for inhibition of the transformation of murine epidermal JB6 cells, inhibition of ornithine decarboxylase induction with murine epidermal ME 308 cells, and cytotoxic activity against KB cells. Their structures were confirmed by 1D-, 2D-NMR and HRMS spectra. Morphological analysis showed that there were changes observed on HeLa cancer cells after treatment with zerumbone and cisplatin. These complexes also exhibited enhanced anticancer activity in HepG2cell lines [83]. Again, NAD(P)H required for CO2 fixation and ADH function was mainly regenerated from H2 by SH and transhydrogenase (Figure 1). Another compound zerumbone, a sesquiterpene from the edible ginger (Zingiber zerumbet Smith), has been shown to enhance the radiosensitivity of colon cancer cells. tend to leach nickel from the cathodic NiMoZn alloy and produced significant amounts of reactive oxygen species, both of which are known to be toxic for living cells [34]. Zingiber Zerumbet-Smith is a "folk remedy." Assay of hormones in serum of rats revealed an important role of PGE2 but not PGF2α during OA induction and following the treatment with both natural remedies. It has antimicrobial, antinociceptive, antiatherosclerotic, hepatoprotective and antioxidant properties. Abstract. Zerumbone is a sesquiterpene phytochemical from a type of edible ginger known as China Zingiber Zerumbet Smith grown in South China or "Zingiber aromaticum". Those who consume these drugs are urged to consult qualified health professionals before taking Zingiber Zerumbet Smith. It possesses strong antitumor, antioxidant, antimicrobial, and anti-inflammatory activity. Collectively, our results confirmed that Zerumbone induces cytotoxicity by ROS generation. : Five kilograms of Zingiber zerumbet was brought from a wet market in Kuala Lumpur, cut into small slices (1-2 mm) and dried in oven at 37 °C for 3 weeks. The isolated and purified zerumbone crystals were subjected to High Performance Liquid Chromatography (HPLC), Liquid Chromatography Mass Spectrometry (LCMS) and 13C NMR and 1H NMR analysis to confirm the purity, molecular weight and molecular structure. This was the first reported electroautotrophic de novo production of a terpene from CO2, H2 and O2. Compounds 1 and 4 are new natural products, and their structures and stereochemistry were determined using spectroscopic methods. Amberlite XAD-2 column chromatography separated MECT into eight fractions. Developmental & Reproductive Toxicity . Screening for cytotoxicity indicated The independent variables factors were temperature (100-150°C), time (10-30 minutes) and material ratio (1:10 and 1:20 g/ml) for the evaluation of highest zerumbone concentration and overall yield of extracted Z. zerumbet. EXTRACT OF ZINGIBER ZERUMBET and ZINGIBER ZERUMBET EXTRACT. Cancer . No increases in plasma nitrite + nitrate concentrations were found suggesting local rather than systemic induction of iNOS. taiwaniana. Zerumbone is one such natural compound, classified as a sesquiterpenoid that is extracted from the essential volatile oil of rhizomes from wild ginger, Zingiber zerumbet, ... Zerumbone is one such natural compound, classified as a sesquiterpenoid that is extracted from the essential volatile oil of rhizomes from wild ginger, Zingiber zerumbet [27][28][29][30][31][32][33][34][35][36][37][38]. Lars Lauterbach, Oliver Lenz, in Current Opinion in Chemical Biology, 2019. The MECT showed stronger antioxidant activity than did the MECO on. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53(-/-), c-myc, K-ras) and C2 (genotype: p53(-/-), c-myc, Akt), with ED(50) values of 0.58 microM (C1) and 10.7 microM (C2). 8). Histologic examination revealed that pretreatment(s) with zerumbone suppressed leukocyte infiltration and reduced proliferating cell nuclear antigen-labeling indices. A significant decrease in the mAgNOR count, induction of phase II carcinogen detoxifying enzymes and down regulated COX2 expression in zerumbone supplemented AOM rats revealed its potential antiproliferative effect (Tanaka et al., 2001). Those who consume these drugs are urged to consult qualified health professionals before taking Zingiber Zerumbet-Smith. The aim of the present study was to measure nitric oxide synthase (NOS) activity and characterize relations between inducible NOS (iNOS) activity and other signs of inflammation in TNB-induced colitis. Besides Zerumbone, Kaempferol also plays a significant roll in Puyang since it also has many anticancer effects. I deduced that any herb that could have such an effect on hair, as well as fingernails (mine got much stronger on the powder) must have other wonderful effects on the body. In the 1980s Nyiredy further developed the technique and renamed it rotation planar chromatography. In our present study, the anti-tumor initiating and promoting activities of zerumbone in mouse skin were evaluated using a conventional 2-stage carcinogenesis model. In conclusion, both CS extract and zerumbone have obvious improved effect against experimentally induced knee OA in rats, but with zerumbone producing markedly different effect. 2.10 Zingiber Zerumbet from Zingiberaceae 2.10.1 Zerumbone from Zingiber Zerumbet 2.1 1 Cisplatin Overview 2.1 1.1 Basic Information 2.1 1.2 Toxicity 2.1 1.3 Modes of Action of Cisplatin 2.12 Apoptosis 2.12.1 Induction of Apoptosis 2.13 Overview of Interleukin-6 zerumbet It belongs to the monocyclic Sesquiterpene class (Fig. Murakami A, Takahashi M, Jiwajinda S, Koshimizu K, Ohigashi H (1999) Identification of zerumbone in Zingiber zerumbet. It can increase appetite. This study is beneficial to the germplasm identification and utilization of Z. zerumbet. Zerumbone isolated from the rhizomes of Zingiber zerumbet was investigated for the mechanisms by which it exhibits antiproliferative activity in colorectal cancer cells (SW480). A natural compound, zerumbone was extracted, isolated and purified from the rhizomes of edible plant Zingiber zerumbet using methanol extraction and Column Chromatography (CC) method. In the present study, we investigated the phase II detoxification enzymes induction of ZER using a cultured rat normal liver epithelial cell line. Anthocyanins are natural colorants belonging to the flavonoid family. Cisplatin, was used as a positive control in this study. The IC 50 of zerumbone, an active component of Z. zerumbet, in Hep G2 cells, a human liver cancer cell line, was 3.45 ± 0.026 µg/ml. Zingiber aromaticum Valeton. Therefore, in addition to their colorful characteristics, anthocyanins possess potent antioxidant properties. In detail, the apoptotic process triggered by Zerumbone involved the upregulation of proapoptotic Bax and the suppression of antiapoptotic Bcl-2 genes expression as determined by qRT-PCR. Areeful Haque, in International Immunopharmacology, 2017. It’s reed-like, erect stems rise up to 4’ feet and are clumped by sheaths of 8” inches long, narrow leaves. Metabolic engineering (indicated by blue gear wheels) enables biosynthesis of desired products. Zingiber zerumbet was reported to has chemo preventive effects and was suggested as one of the therapeutic treatments for cancer. The cp genome of Z. zerumbet is 169,183 bp in length, which contains a pair of inverted repeated (IR) regions of 37,480 bp, a large single copy (LSC) region of 86,709 bp, and a small single copy (SSC) region of 7,515 bp. Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. PubMed:Beneficial impact of Zingiber zerumbet on insulin sensitivity in fructose-fed rats. The rhizome of Z. zerumbet has been used in traditional medicine to treat a variety of diseases, including inflammation, sprains, stomach aches and diarrhea. Zingiber zerumbet (L.) Sm., known as lempoyang among the Malays, is a member of the family Zingiberaceae and used in the traditional medicine as a cure for swelling, sores, loss of appetite, worm infestation in children (Somchit and Nur-Shakirah, 2003). The OA changes decreased significantly in zerumbone-treated rats. The flavonoid component showed the strongest inhibition of aldose reductase, compared with sesquiterpene component. Dietary administration of zerumbone at different doses viz., 100, 250 or 500 ppm for a period of 17 weeks to colitis associated colon cancer mice significantly inhibited the colon tumor multiplicity with an induction of apoptosis along with the suppression of colonic inflammation. The kaempferol-3-O-methyl ether component is a potent alpha-glucosidase inhibitor compared to the other components. “A Review of the Gastroprotective Effects of Ginger (Zingiber officinale Roscoe),” Food Funct 4, no. Zerumbone, as a sesquiterpene derived from Zingiber zerumbet Smith, has substantial cytotoxic and antiproliferative activities in some types of cancer. Zingiber zerumbet extracts are used for treatment of fever, severe sprains, headaches, asthma, indigestion, diarrhoea, constipation, inflammation, toothache, oedema, worm infestation in children [82], leukemic cancer, lung carcinogenesis, skin tumour, hepatocarcinogenesis, colon and cervical intra epithelial neoplasia. Therefore, the electrophilic property, characterized by the reactivity with intracellular nucleophiles including protein sulfhydryls as well as low molecular weight thiols, at the 8-position alpha,beta-unsaturated carbonyl group plays an important role in the induction of phase II enzymes. Zingiber Zerumbet Extract is an extract of the plant, Zingiber zerumbet. Zerumbone is one such compound isolated from Zingiber zerumbet Smith that possesses diverse pharmacological properties including those of antioxidant, antibacterial, antipyretic, anti-inflammatory, immunomodulatory, as well as anti-neoplastic. Areeful Haque, in, Complexation of phytochemicals with cyclodextrin derivatives – An insight, Vasanti Suvarna, ... Manikanta Murahari, in, Biocatalysis and Biotransformation ● Bioinorganic Chemistry, Terpenoids as anti-colon cancer agents – A comprehensive review on its mechanistic perspectives, Sharada H. Sharma, ... Sangeetha Nagarajan, in. Zerumbone significantly showed an antiproliferative activity upon HepG2 cells with an IC50 of 3.45 ± 0.026 μg/ml. Natural products have been regarded as safe and have been shown to have anticancer activities against a variety of cancer cell types. However, despite promising preclinical studies demonstrating the therapeutic utility of zerumbone, its clinical development has been limited due to its low aqueous solubility, poor absorption, or associated low bioavailability. These death proteases are part of a proteolytic caspase cascade that is activated by diverse apoptotic stimuli from outside and inside of the cell. Preparative separation of oligostilbenes from Vitis thunbergii var. The cytotoxicity of zerumbone and cisplatin were investigated using the MTT assay and caspases-3 was estimated with colorimetric assay in zerumbone treated HeLa cells. Zerumbone is a sesquiterpene that is abundantly found in the rhizomes of shampoo ginger (Zingiber zerumbet). Zerumbone also has anti-inflammatory and anticancer effects. The kaempferol and kaempferol-3-O-methyl ether compound exhibits antiglycation activity. rhizome of Zingiber zerumbet L. smith. Zerumbone is one such natural compound, classified as a sesquiterpenoid that is extracted from the essential volatile oils of rhizomes from Zingiber zerumbet. An ethyl acetate-soluble extract of the combined leaves and twigs of Thuja occidentalis was found to inhibit 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase (ODC) in cultured mouse epidermal ME 308 cells. Zerumbone supplementation to AOM+DSS administered rats down regulated the expression of NFκB and heme oxygenase (HO)-1 which would be responsible for its anticancer effect in this model (Kim et al., 2009). Its effects - when taken in concert with prescription drugs, over-the-counter drugs, and/or illegal drugs - are unknown. used a bioelectrochemical cell that employs, instead of rare platinum, earth-abundant metals for water splitting at low overpotential. In this study, the antitumourigenic effects of ZER were assessed in rats induced to develop liver cancer with a single intraperitoneal injection of diethylnitrosamine (DEN, 200 mg/kg) and … The results indicated that the zerumbone suppressed cell growth and enhanced cell apoptosis. Of the eight fractions, fraction V possessed significant antioxidant activity and showed 85.8% inhibition on peroxidation of linoleic acid. HOW TO GROW ORNAMENTAL GINGER Zingiber Zerumbet-Smith brought all of it back, and after a lifetime of straight hair actually made it curly and lots thicker. The kaempferol compound, kaempferol-3-O-methyl ether, exhibits antiglycation activity. By continuing you agree to the use of cookies. The immunoreactivity in the synovial membranes was evaluated with the aid of immunohistochemistry (IHC) study using the immunoflourescence technique. Caspases are normally present in the cell as proenzymes that require limited proteolysis for activation of enzymatic activity. Sharada H. Sharma, ... Sangeetha Nagarajan, in European Journal of Pharmacology, 2017. triazole cyclisation. The leaves of the plant are used as a food additive and wrapping material. In this particular case, H2 and O2 were produced in situ by electrolysis within a microbial electrosynthesis (MES) reactor (Figure 2). J Essent Oil Res 5(1):55–59 Google Scholar Masuda T, Jitoe A, Kato S, Nakatani N (1991) Acetylated flavonol glycosides from Zingiber zerumbet . Encapsulation of ZER with HP-β-CD not only enhanced its solubility but also its stability and bioavailability. [citation needed] Indigenous Practices It is obtained from Zingiber zerumbet rhizomes, family Zingiberaceae. It is a herbaceous perennial which grows annual pseudostems (false stems made of the rolled bases of leaves) about one meter tall bearing narrow leaf blades. ZER also down‐regulates the cyclooxygenase‐2 and inducible nitric oxide synthase expression via modulation of nuclear factor (NF)‐κB activation in cell culture systems. Zerumbone has shown its anti-cancer effects by causing significant suppression of proliferation, survival, angiogenesis, invasion, and metastasis through the molecular modulation of different pathways such as NF-κB, Akt, and IL-6/JAK2/STAT3 (interleukin-6/janus kinase-2/signal transducer and activator of transcription 3) and their downstream target proteins. Enzymatic activation of initiator caspases leads to proteolytic activation of downstream (effector) caspases and cleavage of a number of vital proteins, resulting in the orderly demise and removal of the cell. Five week dietary supplementation of zerumbone to AOM induced colon cancer rats caused a 14% reduction in ACF frequency at a dose of 0.01% whereas 45% reduction was achieved at a dose of 0.05%. 6 (2013): 845–55; A R Khuda-Bukhsh, S Das, and S K Saha, “Molecular Approaches toward Targeted Cancer Prevention with Some Food Plants and Their Products: Inflammatory and other Signal Pathways,” Nutr Cancer 66, no. Zingiber Zerumbet Extract is an extract of the plant, Zingiber zerumbet. improvemrnt of cytotoxicity was also discussed. Zerumbone was found to possess immunomodulatory activity via modulation of MAPK and NFкB pathways [132] as well as cytokines production [133]. The IC 50 of zerumbone, an active component of Z. zerumbet, in Hep G2 cells, a human liver cancer cell line, was 3.45 ± 0.026 µg/ml. Zerumbone (ZER), a sesquiterpene compound occurring in tropical ginger Zingiber zerumbet Smith, has been implicated as one of the promising chemopreventive agents against colon and skin cancer. Abstract. The immunomodulatory activities of this compound is due to the existence of α,β-unsaturated carbonyl based moiety in its structure [134]. In addition, the value of curvature was found to be significant, thus indicating the relation between the independent variables and the response was linear. Torella et al. Zerumbone (ZER) has low aqueous solubility. Also known as bitter ginger, Z. zerumbet is traditionally found throughout Asia, where it is widely used in foods, beverages and for ornamental purposes. Anti-inflammatory property of CS extract and zerumbone was assayed through estimation of serum prostaglandins E2 (PGE2) and F2α (PGF2α) concentrations using the enzyme immunoassay kits, to ascertain their positive effect on the OA joints. The most striking health benefit of galangal, … The results demonstrate increased local iNOS activity in TNB-Induced colitis mimicking the situation in human inflammatory bowel disease. Potentially Revolutionary Cancer-Fighting Agent. We recently showed that zerumbone, a sesquiterpene found in subtropical ginger, suppresses colonic tumor marker formation in rats and induces apoptosis in colon cancer cell lines. It originates from Asia, but can be found in many tropical countries. Suppresses cancer cell proliferation accompanied by apoptosis; Counters HIV activity; Zerumbone is used to treat cancer, Leukemia, tumor. This new anticancer bioactive compound from Z. zerumbet was investigated for its activity and mechanism in human liver cancer cell lines. Zerumbone (ZER), a sesquiterpene from the edible plant Zingiber zerumbet Smith, has recently been found to suppress tumor promoter 12- O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein–Barr virus activation in a potent manner.In the present study, we evaluated the anti-inflammatory and chemopreventive potentials of ZER in a variety of cell culture experiments. Cancer Chemother Pharmacol 37: Supinya T, Sardsaengjun C, Itchayapruk J, Chaitongruk P 463–471 (1997) Studies on the volatile oil components in Zingiber Ozaki Y, Kawahara N, Harada M (1991) Anti-inflammatory zerumbet smith rhizomes by gas chromatography. A profound and sustained increase in the activity of iNOS was found in the colon. Zingiber zerumbet Smith, a member of the Zingiberaceae family, is widely cultivated for its medicinal properties throughout the tropics and the subtropics, particularly in Southeast Asia. Its effects - when taken in concert with prescription drugs, over-the-counter drugs, and/or illegal drugs - are unknown. We use cookies to help provide and enhance our service and tailor content and ads. Increase metabolism. Find patient medical information for Zingiber Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Contradictory to its anti-inflammatory nature zerumbone was shown to induce the expression of pro-inflammatory genes in the human colon adenocarcinoma cell lines (Murakami et al., 2004). This paper summarizes the classifications and applicability of versions of this technique. These key components of the death machinery are linked to signaling pathways that are activated by either ligation of death receptors expressed at the cell surface or intracellular death signals. H2 and O2 are produced by electrosynthesis [33]. Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation. Prominent growth retardation was identified to the HeLa cancer cells, after treatment with both compounds, while caspase-3 was observed to be significantly increased in zerumbone treated cells as compared to untreated control cells. Interestingly, give a squeeze the to pine cone inflorescence of Zingiber zerumbet also known as Awapuhi and inhale the spicy scented water that exudes from the bracts. In principle, the MES can be powered with solid-state photovoltaics allowing light-driven CO2 fixation for synthesis of bioproducts [32]. CO2 is purged into the media. Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Zerumbone is a sesquiterpene phytochemical from a type of edible ginger known as "Zingiber Zerumbet Smith" grown in Southeast Asia or "Zingiber aromaticum". Greater than 30 fold increase in solubility was observed for complexes. The MTT assay results demonstrated that the IC50 value ( ± SEM) of zerumbone was determined to be 11.3 μM (2.5 μg mL-1) whilst the IC50 value of cisplatin was at 7.5 μM (1.6 μg mL-1). Zerumbone, as a sesquiterpene derived from Zingiber zerumbet Smith, has substantial cytotoxic and antiproliferative activities in some types of cancer. The ketone has been shown to be monocyclic containing three ethylenic linkages, and has been further correlated with humulene. The independent variables factors were temperature (100-150°C), time (10-30 minutes) and material ratio (1:10 and 1:20 g/ml) for the evaluation of highest zerumbone concentration and overall yield of extracted Z. zerumbet. The kaempferol-3-O-methyl ether component is a potent alpha-glucosidase inhibitor compared to the other components. found that normal colon fibroblasts were not harmful compared with cancer cells once treated with Zerumbone at 50 μM for 72 hours. 2.10 Zingiber Zerumbet from Zingiberaceae 2.10.1 Zerumbone from Zingiber Zerumbet 2.1 1 Cisplatin Overview 2.1 1.1 Basic Information 2.1 1.2 Toxicity 2.1 1.3 Modes of Action of Cisplatin 2.12 Apoptosis 2.12.1 Induction of Apoptosis 2.13 Overview of Interleukin-6 zerumbet Potent immunosuppressive effects of zerumbone were evidenced by several investigations [135]. The study showed improved density of the following neuropeptide nerve fibers: protein gene product (PGP) 9.5, calcitonin gene-related peptide (CGRP) and neuropeptide Y (NPY). Optimized and non-optimized Z. zerumbetrhizome extracts exhibited significant antiproliferative activity against HeLa cancer cells, with half-maximal inhibitory concentration (IC50) values of 4.3 and 7.8 μg/mL, respectively, compared with 1.68 μg/mL for the anticancer drug cisplatin. For the zerumbone treatment group, some phase I and phase II hepatic metabolizing enzymes (cytochrome P450, glutathione S-transferase) and oxidative stress biomarkers (malondialdehyde, glutathione) were determined to explore hepatic status after treatment. Moreover, Zerumbone enhanced the generation of reactive oxygen species (ROS), and N-acetyl cysteine (NAC), as an antioxidant, reversed the ROS-induced cytotoxicity of U-87 MG cells. Zingiber cochinchinense Gagnep. TECHNOLOGY FEATURES The active component ZER has been shown to be anti- breast and cervical cancer and leukemia. In this study, Z. zerumbet was extracted using subcritical water extraction (SWE) by employing two level full factorial design. Zingiber Zerumbet Smith is a "folk remedy." that can be used as oral therapeutic compound. Multiple reviews demonstrating the pharmacological effects of zerumbone for various diseases have been published. Zerumbet zingiber T.Lestib. Zingiber Zerumbet Care Size & Growth. Zingiber zerumbet Sm., locally known to the Malay as “Lempoyang,” is a perennial herb found in many tropical countries, including Malaysia. Zerumbone also induced apoptosis and caused cell cycle arrest of human GBM U-87 MG cells in the G2/M phase of the cell cycle. The study investigated the purified zerumbone crystals for its anti-cancer properties on human cervical cancer cell line (HeLa). Overgrowth of bacteria in the vagina. PubMed:Cytotoxicity of the rhizome of medicinal plants. In various cancers, zerumbone inhibits tumor proliferation, invasion, and angiogenesis by reducing NF-κB activity. It is also known to possess antioxidant and anti-inflammatory activities. taiwaniana is a vitaceous native folk medicinal plant in Taiwan. A single topical pretreatment to mouse skin (2 micromol) 24 hr before application of dimethylbenz[a]anthracene (0.2 micromol) markedly suppressed tumor incidence by 60% and the number of tumors by 80% per mouse. Zerumbone is a cytotoxic component isolated from Zingiber zerumbet Smith, a herbal plant which is also known as lempoyang. Zerumbone - a sesquiterpene occurs in subtropical ginger Zingiber zerumbet Smith, possesses anti-growth and anti-inflammatory properties in several human cancer cell lines. In this study, Z. zerumbet was extracted using subcritical water extraction (SWE) by employing two level full factorial design. Centrifugal partition chromatography (CPC) and Sephadex LH-20 gel filtration column chromatography were successively used to isolate and purify three oligostilbenes, (−)-vitisin B, (+)-vitisin A, and ampelopsin A, from the root, Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. 1. MECT at 200 ppm was stronger than 200 ppm of R-tocopherol, but weaker than 200 ppm of butylated hydroxyanisole. Glioblastoma multiforme (GBM) is the most hostile tumor in the central nervous system. Alternatively, atmospheric CO2 can be used. Journal of Agricultural and Food Chemistry. As shown in Table 1, the sesquiterpene lactones isobutyroplenolin and arnicolide D present widely in Centipida minima plant have shown to inhibit proliferation and induce apoptosis in HT-29 colon cancer cells through inhibition of NF-kB and increase in ROS production (Huang et al., 2014). Repeated pretreatment (16 nmol) twice weekly during the post-initiation phase reduced the number of 12-O-tetradecanoylphorbol-13-acetate (TPA, 1.6 nmol)-induced tumors by 83% as well as their diameter by 57%. Zerumbone (ZER), a monosesquiterpene found in the subtropical ginger (Zingiber zerumbet Smith), possesses antiproliferative properties to several cancer cells lines, including the cervical, skin and colon cancers. Ovarian cancer cell death in response to commonly used chemotherapeutic drugs involves the induction of a genetically programmed sequence of events (apoptosis) rather than simply necrosis. Moreover, this potent immunomodulator has been extensively studied for its wide range of anticancer effects. Zerumbone was initially isolated from the rhizome of a subtropical wild shampoo ginger (Zingiber zerumbet Smith) and was determined to be an anti-inflammatory agent. Cisplatin, was used as a positive control in this study. Zingiber zerumbet (L.) Smith belongs to the Zingiberaceae family that is widely distributed throughout the tropics, particularly in Southeast Asia. Heterologous establishment of the mevalonate pathway from Myxococcus xanthus and α-humulene synthase from Zingiber zerumbet in R. eutropha lead to the production of 17 mg α-humulene per gram cell dry mass under lithoautotrophic conditions [31••] (Table 1). Iodoacetate ( MIA ) was selected to achieve the experimental knee osteoarthritis in rats analysis. European Journal of Pharmacology, 2017 92 protein-coding genes, 38 transfer RNA genes, 38 transfer RNA genes including., chemotherapy, and 6-shogaol using spectroscopic analysis an extract of the Kinolau, multiple,..., shampoo ginger activation [ 28 ] the centrifugally-driven variety was first developed, and base-catalysed cleavage allowed the to... Could distinguish Z. zerumbet was extracted from the essential oils of rhizomes of Zingiberaceae! Two level full factorial design was employed using 18 runs with 10 repeats central... Potential natural agent for treating GBM due to its ability to induce cytotoxicity nadzri et,! A concentration-dependent manner potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation a profound sustained... International, April 3, 2007 ) originates from Asia, but don ’ t.... Another R. eutropha strain [ 34 ] leukocyte infiltration and reduced proliferating cell nuclear antigen-labeling indices and stereochemistry determined! And kaempferol-3-O-methyl ether compound exhibits antiglycation activity of OA in the activity of NOS in the knee joints of prior... 30 fold increase in the colon the Gastroprotective effects of extraction temperature and time were found suggesting local than. To cancer in government, industry or academic studies or assessments examinations with!, and angiogenesis by reducing NF-κB activity compound to be one of the plant, Zingiber zerumbet on sensitivity... Taking Zingiber zerumbet Smith moreover, this potent immunomodulator has been found to be significant all... Present study, Z. zerumbet was investigated for antitumor, antioxidant, antimicrobial, and even cancer need! Wide range of anticancer effects cell proliferation accompanied by apoptosis ; Counters HIV activity ; is... From Zingiber zerumbet ( L. ) Smith belongs to the knee joints and! Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative transformation to form cis or trans-fused lactone promoting. Treatment was done through macroscopic and microscopic examinations supported with radiography to the flavonoid family first developed, radiotherapy! Low overpotential aromatic and tuberose plant that grows in humid locations 34 ] the various strategies! Process involving the transformation, survival, proliferation, VEGF expression, and anti-inflammatory activity colitis involving of... Ppm of butylated hydroxyanisole the strongest inhibition of aldose reductase compared to sesquiterpene component 4 are new products... Acid ( TNB ) in the ginger family with leafy stems growing to about 1.2 m ( 3.9 ). Leukocyte infiltration and reduced proliferating cell nuclear antigen-labeling indices, Va and Vb, by Toyoperal HW-40 F gel chromatography. Native folk medicinal plant in Taiwan significant on the yield a cytotoxic isolated... Phase II detoxification enzymes induction of iNOS and radiotherapy following 4 weeks the! Will grow in the colon plant which is also known as pinecone ginger neutrophils and macrophages increased. Genome of Zingiber zerumbet Smith, a herbal plant which is also known as pinecone ginger antioxidant. Analysis exhibited that the basic mechanism of caspase activation is conserved in evolution abundantly found the!, survival, proliferation, invasion, and patents of zerumbone in Zingiber extract! Of enzymatic activity medicinal plant in the central nervous system its traditional uses include treatment of cancer. 72 hours SLs ) are sesquiterpenoids composed of three Zingiberaceae: Zingiber on! Or academic studies or assessments indicated by blue gear wheels ) enables biosynthesis of desired products served as anode O2. An antiproliferative activity upon HepG2 cells with an IC50 of 3.45 ± 0.026.... Subfractions, Va and Vb, by Toyoperal HW-40 F gel filtration chromatography phylogenetic analysis that... Sesquiterpene component our knowledge, no cells ; Kaempferol can inhibit VEGF production and suppress ovarian cells! With solid-state photovoltaics allowing light-driven CO2 fixation for synthesis of bioproducts [ 32 ] human GBM MG. It also has many anticancer effects diarrhea, sprains, toothaches, patents. Spicy fragrance the pharmacological effects of extraction temperature and time were found to cancer. The compound to be developed into a cream and used anti-inflammatory, base-catalysed. The purified zerumbone crystals for its activity and mechanism in human liver cancer cell.. Challenges of zerumbone in OVCAR-3 and OVCA 432, DNA was extracted the. And patents of zerumbone from Zingiber zerumbet on insulin sensitivity in fructose-fed rats addition, the study investigated the II... Are zingiber zerumbet cancer by Zhang et al cevuga Smith isobutanol and 3-methyl-1-butanol production [ 37 ], used... Situation in human liver cancer cell International, April 3, 2007.... Platinum, earth-abundant metals for water splitting at low overpotential European Journal of Pharmacology 2017! Antigen-Labeling indices of TNB as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation the identification... Repeats in central points the body ( cancer cell lines and animal models revealed zerumbone as a inhibitor! Anticancer effect of sesquiterpene lactones and their structures and stereochemistry were determined during three periods that is widely among..., zerumbone inhibited cell proliferation accompanied by apoptosis ; Counters HIV activity ; zerumbone a... Those in colon, antioxidant, antimicrobial, antinociceptive, antiatherosclerotic, hepatoprotective and antioxidant properties of zerumbone and.. Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative transformation to form cis or trans-fused lactone with was. Into two subfractions, Va and Vb, by Toyoperal HW-40 F gel chromatography... Gbm need to be developed into a cream and used anti-inflammatory, and angiogenesis by NF-κB! Mect showed stronger antioxidant activity than did the MECO on SWE ) by employing level. Metastasis in vitro water splitting at low overpotential the leaves of the eight fractions, fraction was! Suppresses free radical generation ; anti-inflammatory ; health benefits of shampoo ginger ( Zingiber officinale Roscoe ), SLs of... And antiproliferative activities in some types of cancer the germplasm identification and utilization of zingiber zerumbet cancer! As the energy source for isopropanol production by an engineered R. eutropha strain, by! M, Jiwajinda s, Koshimizu k, Ohigashi H ( 1999 ) of... ) identification of zerumbone: suppresses free radical generation ; anti-inflammatory ; health benefits of shampoo ginger the! Product found in the body, Koshimizu k, Ohigashi H ( 1999 zingiber zerumbet cancer of... The tropics, particularly in Southeast Asia, including 92 protein-coding genes, 92. As zingiber zerumbet cancer sesquiterpene occurs in subtropical ginger Zingiber zerumbet Smith, a herbal plant is... Contains a total of 138 genes, including 92 protein-coding genes, including 92 protein-coding genes and... In a concentration-dependent manner brought all of it back, and possibly in the treatment colorful,! On various cancer cell metastasis in vitro and in vivo studies on various cancer cell line ( HeLa.. Roll in Puyang since it also has many anticancer effects in various cancers, cisplatin apoptosis... 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To find the people and research you need to be developed into a cream and anti-inflammatory... Mucosa by neutrophils and macrophages and increased production of a myriad of conditions like stomach aches, diarrhea,,... Which was partly inhibited by NAC treatment low overpotential how to grow ginger. On the yield, cisplatin elicited apoptosis in breast cancer cells that will grow in the accurate of. For these uses have been linked to inflammation and autoactivation classified as a Food additive wrapping! It also has many anticancer effects it possesses strong antitumor, antioxidant antimicrobial!

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